【摘要】 在53名中、老年正常人和66例NIDDM患者中,根据胰岛素分泌指数和红细胞膜胰岛素受体分析的结果表明,正常老年人胰岛素分泌量增多,而末梢组织对胰岛素的敏感性则降低,红细胞膜胰岛素受体数和结合率也降低,此可能系正常老年人糖耐量减退的主要原因之一。中、老年糖尿病患者胰岛素分泌指数、胰岛素受体数以及胰岛素结合率均明显低于正常老年人。对中、老年糖尿病的诊断和治疗作了讨论。治疗重点为饮食调节、适当运动、控制肥胖和高血压。降糖药物以能提高末梢组织利用葡萄糖的磺脲类药物为首选,过程中要防止发生血糖过低症。更多还原

【Abstract】 The insulinogenic index and RBC membrane insulin receptor analysis in 53 middle-aged and senile normal subjects and 66 cases of NIDDM showed that the amounts of insulin secreted in middle-aged and senile normal subjects were increased, whereas the insulin sensitivity of peripheral tissues and the numbers of RBC insulin receptors were decreased This might be one of the causative factors for glucose intolerance in middle-aged and senile normal subjects. In middle-aged and senile diabetics,the insulinogenic index,the insulin receptor number and the insulin binding capacity were lowered conspicuously than those in normal subjects with similar age.The diagnosis and treatment of senile diabetes were discussed. As to the management, stress may be placed on diet regulation, suitable physical exercise to prevent and control obesity and hypertension, etc. As long as hypoglycemic agent is indicated, sulfonylurea drugs capable of enhancing the glucose utilization in peripheral tissues should be the drug of choice and hypoglycemia be specially watched during the course.更多还原