【摘要】 本文对35例糖尿病病人姊妹染色单体互换(SCE)频率的变化及其影响因素进行了研究,发现病人自发SCE频率与丝裂霉素C诱发的SCE频率比正常人显著增高,自发频率与诱发频率间存在高度的正相关。病人的自发SCE频率与糖化血红蛋白间无相关关系。高浓度葡萄糖或大剂量普通胰岛素均不能使正常人SCE频率增高,服D860治疗的病人之SCE频率并不比初诊病人高。本文对糖尿病孕妇胎儿死产、流产及畸形率高的原因、染色体稳定性以及药物致畸等方面进行了讨论。更多还原

【Abstract】 Sister chromatid exchange (SCE) frequencies were investigated in 35 diabetics and 24 controls. The spontaneous and MMC-induced SCE frequencies in diabetics were obviously higher than those in controls. There was a significant positive correlation between the spontaneous and MMC-induced SCE frequencies in either diabetics or controls. No correlation was found between the spontaneous SCE frequencies and HbA1 . High concentrations of glucose or regular insulin in the culture medium could not increase SCE frequencies of the controls. No significant difference was found between the untreated patients and patients treated with tolbutamide. The increased SCE frequency in diabetics may account for higher incidence of fetal stillbirth, abortion and malformations in diabetic pregnancies.更多还原