【摘要】 本组1958—1977年1,021例乳腺癌与日本癌研会病理室1956—1975年2,604例及美国Vander-bilt大学1956～1976年755例乳腺癌为基本材料进行了临床对比研究分析。另外选用我所113例乳腺癌激素受体检查结果与1977年美日合作报告的对比材料进行了比较。结果表明,中国妇女乳腺癌所具有的特点与日本相似,而与美国显著不同。中日地区与美国比较,美国乳腺癌的发病率及死亡率高于中、日4—5倍。日本乳腺癌的预后明显较美国为好,日本乳腺癌10年存活率为63.8％,而美国为46.9％。本文分析证明,中国妇女乳腺癌预后接近日本。中、日两国乳腺癌发病年龄相同,而较美国提前一个年龄组(10年),中、日两国发病年龄高峰位于40—49岁,中年为多,美国发病年龄高峰则位于50—59岁,以老年人为多。年龄与预后关系,三国比较未见明显差别,所有乳腺癌患者均以40—49岁年龄组预后最好。组织类型,美国小叶癌多发,较中、日高10倍左右。肿瘤大小及淋巴结转移对生存率的影响,各国间未见差别。乳腺癌雌激素受体测量表明,中国、日本妇女乳腺癌ER水平较美国低,并且不随年龄及月经情况而变化。乳腺癌以上临床病理的地区性差别,为研究乳腺癌的发生及影响预后的因素提供了重要依据。更多还原

【Abstract】 The clinical and pathological features of 1,021 cases of mammary carcinoma in Chinese female treated in 1958-1977 compared with those of 2,604 cases in Japanese 1956-1975 and 755 cases in Americans 1956-1976 were studied. This study demonstrated that the characteristics of breast cancer in Chinese women were similar to those of Japanese but different from Americans. (1) The incidence and mortality rate of breast cancer in American women were 4-5 times higher than Chinese and Japanese. (2) The prognosis of Japanese breast cancer was distinctly better than Americans in that the 10-year survival rate was 63.8% in Japanese and only 46.9% in Americans. (3) The peak age incidence in Chinese and Japanese female (40-49 years) was one decade younger than Americans (50-59 years of age). (4) Comparing histologic type of carcinoma, the frequency of lobular carcinoma of breast was 10 times higher in USA patients. (5) No striking disparity among the three nations was observed in relation with prognosis as to age of patients, size of primary tumor and number of lymph nodes involved. (6)The ER assay in breast carcinoma tissue showed that ER level was lower in Chinese and Japanese.更多还原