【摘要】 本文以6-取代香豆素-3-羧酸与头孢菌素母核缩合,合成了15个未见文献报道的6取代香豆素-3-甲酰胺头孢菌素化合物。其合成方法采用了Vilsmeier试剂法,改进了溶媒及摩尔配比,并进一步探索了分离纯化的过程,以元素分析、IR及NMR确证结构。抑菌试验表明,对某些革兰氏阳性菌具有不同程度的抑菌作用,而某些革兰氏阴性菌的效果则不明显。更多还原

【Abstract】 Fifteen novel derivatives of the 6-substituted-coumarin-3-formamido cephalosporins were obtained by reacting 6-substituted coumarin-3-carboxylic acids with four cephalosporin-nuclears. Vilsmeier reagent method was mainly employed in the procedure of the condensation. Some improvements were made on the solvent system used in the reactions and the mole ratio of the starting materials. In addition, the seperation and purification of the final products were studied. The antibacterial sensitivity test showed that most of these novel derivatives exhibited gram-positive bacteriostatic activities, but there was no action aganist gram-negative bacteria observed.更多还原