【摘要】 <正> 消旋体四氢巴马汀(dl-tetrahydropalmatine,THP),是从罂栗科紫堇属植物延胡索中提取的一种生物碱,有镇痛、镇静、催眠、舒张平滑肌、降压等作用。近来发现,THP还有广泛的抗心律失常作用,其作用机理相当于Ⅳ类抗心律失常药,为一类似戊脉安的钙通道阻滞剂。本文观察了THP对麻醉开胸犬的血流动力学作用,为探索THP的作用机理及今后临床用药提供一定的参考。更多还原

【Abstract】 The two-way effects of dl-tetrahydropalmatine （THP） on cardiac hemodynamics were examined in 8 anesthetized open-chest dogs. Intravenous injection of THP （5 or 15 mg/kg） produced a dose-dependent positive inotropic effect rapidly. The left ventricular systolic pressure （LVSP）, maximal rate of change of intraventricular pressure (dp/dt_max) and cardiac index （CI） were increased significantly, then decreased rapidly. Systolic blood pressure （SBP）, diastolic blood pressure （DBP）, V_CE at dp/dt_max (V_CE-dp/dt_max) and total peripheral resistance （TPR） were decreased. The time constant of isovolumic diastolic pressure decay (T_value) was increased after drug administration. When marked depression of cardiac contractility appeared after drug administration, CI decreased slightly.更多还原