【摘要】 <正> 近年来,有关自由基与癌的研究已被广泛重视.羟自由基（·OH）是最强的氧化剂之一,甚至能引起连KMnO₄都不能引起的反应。·OH具有细胞毒素,因此·OH自由基抑制剂的研究,将会对癌的预防和治疗有一定作用。实验证明阿糖胞苷对羟自由基有一定的清除作用,其清除率随药物浓度的增加而加大,同时证明它对羟自由基的生成速率也有一定抑制作用。更多还原

【Abstract】 The cell damages caused by superoxide free radical （O₂^-） include a series of biochemical processes, including lipid peroxidation, DNA and chromosomal damage as well as deactivation of enzyme. It has been suggested that the intrinsic attacking agent is hydroxyl free radical （.OH）, which is generated through Fenton reaction. Thus, any .OH scavenging agent may inhibit the relevant cell damage. Cytosine arabinoside was found to be able to scavenge .OH generated by Co⁶⁰ radiolysis and Fe（11）-EDTA with H₂O₂ in aqueous solutions. Determination of the fluorescence of hydroxylated derivatives from benzoate was used to estimate the level of .OH. The scavenging percentage and inhibition ratio of .OH by cytosine arabinoside were measured.更多还原