【摘要】 根据拼合原理,设计并合成了19个1-（2-羟基-3-芳氧基丙基）-4-芳酰基哌嗪类化合物。对其中8个化合物I₁～I₈进行了药理试验,发现它们有明显的降压活性及α-受体阻滞活性。更多还原

【Abstract】 Nineteen 1-（2-hydroxy-3-aryloxypropyl）-4-aroylpiperazines were designed according to synbiotic approach and then synthesized. Eight of them （from I₁ to I₈） were subjected to preliminary pharmacological assay. They were shown to have α-adrenergic blocking and hypotensive activities.更多还原