【摘要】 <正> 脂质体(liposome)60年代末问世以来,一直引起国内外研究者极大的兴趣,许多学者对脂质体药物的靶向性特征及治疗学上的意义进行了大量研究。多相脂质体139(油酸多相脂质体)在物理化学稳定性上都达到静滴标准,我们又更多还原

【Abstract】 The methods on observation of the pattern of polyphase liposome and on determination of size and distribution of particles and particulate matter of intravenous injection of polyphase liposome (139) in the form of suspension are presented in this paper. Microscopic photographs of the injection of polyphase liposome (139) demonstrated the structure of artificial cell of polyphase liposome. With Coulter counter (TAⅡ) and microscope-micrometer the size and distribution of particles in the injection of polyphase liposome (139) in the form of suspension is shown. The results of measurement by the two methods are the same, especially the results on size of the large particles in the injection (139). Moreover, the membrane filter-microscope method described in USP ⅩⅩ for measureing the particulate matter in large-volume injection for single dose infusion was improved. The improved method was used in the determination of particulate matter in the intravenous injection of polyphase liposome (139) in the form of suspension. This method is not only more accurate but also more simple and convenient than the original USP ⅩⅩ method.更多还原