【摘要】 <正> 铀化合物在国防和国民经济建设中的重要性及其对人体的危害性日益为人们所知。为此对铀的防护和解毒药物的研究已日益引起各方面的关注,但迄今仍未见找到理想的解毒药物。文献报道钛铁试剂和phosphicine在动物试验对铀化合物的促排效果较好。另外,更多还原

【Abstract】 In searching for new chelation therapy drugs against uranium intoxication, a series of N-carboxymethyl-N-(substituted carbamoylmethyl)-2, 3-dihydroxy-5-carboalkyloxybenzylamine was synthesized starting with 2, 3-dihydroxy-5-carboalkyloxybenzylamine diacetic acid. The effect on the elimination of uranium salts from animal bodies was tested. Four of them (Ⅳ_n, Ⅳ_q, Ⅳ_u and Ⅳ_v) were shown to be more effective than tiron or phosphicine in accelerating uranium excretion in rats.更多还原