【摘要】 <正> 角膜移植术是防盲治盲的重要手段。为扩大角膜来源,不断有学者进行异种角膜移植之研究。在供体选择、组织学观察方面有所进展。但免疫反应仍是影响异种角膜移植的主要因素。为探讨异种角膜移植术后免疫系统变化特点及发生排斥反应的机理,我们以鸡对兔异种板层角膜移植为实验模型,动态测定了受体手术前后特异性体液免疫和非特异性细胞免疫状态,报告如下。更多还原

【Abstract】 This study was to investigate the immune reaction of experimental heterogous lamellar corneal transplantation (chick to rabbit). Specific humoral and non-specific cellular immunities were determined dynamicly by ELISA and micro-whole blood ~3H-TdR incorporation respectively. The results showed that the level of specific anti-cornea antibody was increased significantly after two weeks postoperatively in serum and tears. The peak level was the third week, and decreased after the fouth week. The level in tears was in lower than that in serum, but there was correlation between both of them. It has also found that the transfomational degree of peripheral lymphocytes was the highest in the third week. These results indicated that heterokeratoplasty could induce immune rejection significantly from two to four weeks after oper ation. If the anti-rejective treatment is to use at this time, the results may be better.更多还原