【摘要】 以表雄酮(1)为原料,由中间体3β-羟基-5α-雄甾-16-烯(3)合成3β,17α-二羟基-16α-氨基-5α-雄甾烷(7)和它的16β-氨基异构体(10a);由中间体3β-羟基-16α-溴-5α-雄甾-17-酮(12)合成3β,17β-二羟基-16α-氨基-5α-雄甾烷(21)和它的16β-氨基异构体(15)。上述四个立体异构体均通过化学转化以及波测试谱确证了其构型。更多还原

【Abstract】 Starting from epiandrosterone (1),intermediates 3β-hydroxy-5α-androst-16-ene(3) and 3β-hydroxy-16 α-bromo-5α-androst-17-one(12) were synthesized.Then3β ,17α-dihydroxy-16α-amino-5α-androstane(7) and its 16β-amino isomer (10a)wereobtained from 3;3β,17β-dihydroxy-16α-amino-5α-androstane (21) and its 16β-aminoisomer(15) from 12.The configurations of these four stereoisomers were confirmed viachemical conversions and spectral data.更多还原