【摘要】 本文报告了105例慢性粒细胞白血病(简称慢粒)的染色体检查结果。其中103例(98.1%)为Ph~1染色体阳性,包括1例复杂的Ph~1易位和1例遮蔽的Ph~1易位。2例(1.9%)为Ph~1染色体阴性。骨髓Ph~1(+)细胞总出现率为95.4%。14例慢粒急变患者中10例伴有额外的染色体异常(71.4%),最多见的改变为2Ph~1、i(17q)和+8。并结合文献就Ph~1阴性慢粒的重新评价,骨髓Ph~1(+)细胞出现率和治疗的关系,慢粒急变的染色体变化及其预后意义等作了简要讨论。更多还原

【Abstract】 The results of chromosomal determination for 105 patients suffering from chronicmyelogenous leukemia (CGL-chronic granulocytic leukemia) were reported.103 cases(98.1%) were Ph~1 chromosome positive,including one case with a complicated Ph~1 translo-cation and another one with a masked Ph~1 translocation.The remaining two cases (1.9%)of the series were Ph~1 chromosome negative.Bone marrow cells were found to be 95.4%positive for Ph~1.Among 14 cases with blastic crisis,ten cases had additional chromosomeabnormalities,of which 2Ph~1,i(17q) and+8 were the most common changes.Reevaluation of Ph~1 negative CGL cases,the relation between frequence of Ph~1 positive cells andthe course of the disease and/or the treatment,and finally the prognostic significance ofchromosomal abnormalities of CGL in blastic crisis were briefly discussed in the paper.更多还原