【摘要】 1982年7月四川省凉山彝族自治州从苏格兰购回2岁左右的边区莱斯特种羊115只。1983年4月、5月和12月,先后发现其中有2只母羊和3只1岁的纯种后代羔羊出现明显的搔痒与神经症状,经检查未见螨和虱等外寄生虫。两只母羊因迅速失重、极度衰竭,先后于濒死期剖杀。尸体剖检无明显病变。病理组织学检查,在中枢神经系统的脑干(延髓、脑桥、丘脑和纹状体)呈两侧对称性损害,出现特征性的空泡性神经元(所谓“气球样细胞”),灰质不同程度的海绵状变性和星形胶质细胞的肥大与增生等病变。 取脑和脾作细菌培养为阴性,以病羊脑悬浮液接种家兔未发病。 诊断是以呈现典型的痒病症状和脑内的组织损害为依据。更多还原

【Abstract】 This paper reports the occurrence of scrapie in 115 2-year-old Border Leicester sheep imported from Scotland. From April to May and in December of 1983, two ewes and three purebred filial sheep showed pruritus and nervous signs. No mites and lice were found in itching areas, and the two affected ewes lost weight rapidly and became extremely debilitated. They were killed at the agonal stage. There were no apparent gross lesions at necropsy. Microscopical examination showed characteristic vacuolated neurons ( so-called " bubble cells " ) , spongy rarefaction of the gray matter and hypertrophy and proliferation of as-trocytes in brain stem ( medulla, pons, thalamus and corpus striatum ) of the central nervous system. The lesions were bilaterally symmetrical. The diagnosis was based upon the clinical signs and characteristic patho-histological lesions of the central nervous system.更多还原