【摘要】 <正> 在针刺镇痛的研究中发现,针刺效果与脑内的脑啡肽等物质及鸦片受体有关。我们曾观察到,电针镇痛时,外源性配体(~3H-etorphine)与鸦片受体的结合明显减少,提示电针时内源性脑啡肽大量增加并占据了鸦片受体,因而推论鸦片受体与脑啡肽的结合,是针刺镇痛的重要环节之一。现已有报道,电针耐受时脑内脑啡肽的含量仍处于高水平而镇痛效果却明显下降。为了解此时鸦片受体与配体结合的变化进行了以下实验。更多还原

【Abstract】 The changes of opiate receptor binding under electroacupuncture tolerance were studied in rat brain by autoradiography. Comparing with the results of electroacupuncture analgesia,the opiate re- ceptor binding was reduced significantly in rat brain after electroacupuncture tolerance.The nervous nuclei where the receptor binding decreased prominent- ly were:the dorsal part of cornu posterius,of the spinal cord,substantia grisea centralis medullae spinalis,nucleus tractus spinalis nerve trigemini,lo- cus coeruleus,raphe magnus,mucleus nucleus raphe dorsalis,substantia nigra, nucleus interpeduncularis cularis,substantia grisea centralis of mesencephalon, nucle ihabenulae,nuclei hypothalami,nuclei amygdalae,nucleus accumbens,etc. The authers point out that the nuclei involved in the electroacupuncture tolerance were the same to those in the electroacupuncture analgesia.The causes of the decrease of opiate receptor binding were disscused.更多还原