【摘要】 给七只成年健康奶山羊单剂量快速静注 TMP（10mg/kg）后,六小时内不同时间采血,用反相高效液相色谱（RP—HPLC）法测定血清 TMP 浓度,以残量法拟合药一时曲线得最佳方程为:■=11.64e-5.4039t+1.47e-0.757t.其它动力学参数如下:Co:13.11±2.68μg/ml;t_1/2α:0.15±0.06h;t（1/2）β:0.94±0.19h;Vd:3.4921±1.3285L/kg;AUC:4.29±1.35h·μg/ml;K₁₂:1.6581±1.2942h^-1;k₂₁:1.2276±0.3234h^-1;k₁₀:3.2761±0.8732h^-1;Cl:2.5328±0.7768L/kg;tcp（ther）:2.33h.更多还原

【Abstract】 Pharmcokinetics（pk）of distribution and elimination of TMP in seven normal adult milk goats was reported.TMP was administrated intravenously by a single dose,10mg/kg of their body weight.Blood samples were collected at the dif- ferent time within 6 hours after the drug was given.The concentrations of TMP in the serum samples were determined by the RP-HPLC method.The serum concentration-time curves of the drug fitted a two-compartment open model: C=11.64e^-5·4039t+1.47e^-0·7578t.The other parameter values of PK in milk goats are described as follow: Co:13.11±2.68μg/ml;t1/2:0.15±0.06h; t1/2:0.94±0.19h;Vd:3.4921±1.3511/kg;V₁:0.7891±0.1511/kg; AUC:4.29±1.33hμg/ml;K₁₂:1.6581±1.2942h^-1; K₂₁:1.2276+0.3234h^-1;K₁₀3.2761±0.8732h^-1; Cl:2.5328±0.77681/kg.h:tcp（ther）:2.33h. The results showed that TMP is a kind of short-action drug for milk goats.更多还原