【摘要】 1.大骨节病患区和邻近非患区不同硒水平儿童尿羟赖氨酸排出情况不同,凡是尿硒排出量低的儿童,其尿羟赖氨酸排出量也低,二者存在高度正相关关系。2.低硒儿童尿羟赖氨酸排出减少被认为可能与前α-肽链上赖氨酸羟化不全有关。3.本文着重对大骨节病儿童分组指标的选择做了详细讨论,指出合理分组是获得生化代谢变化正确信息的基础。更多还原

【Abstract】 The urinary Se and hydroxylysine contents were determined in 162 cases from Kasehin-Beek disease affected and non- affected areas.The results showed that the urinary hydroxylysine outputs were lower in children with lower Se levels than with highter Se ones.There was a close relationship between urinary Se and hydro- xylysine outputs (r=0.97,n′=3,p<0.01). Both hydroxylysine and hydroxyproline contents in urine were greatly decrea- sed in children with Se deficiency.This suggested that the hydroxylations of lys- ine and Proline might be inhibited by Se deficiency in the children with low Se status.更多还原