【摘要】 醋酸棉酚能兴奋雌激素化小鼠和豚鼠的离体子宫,对孕激素化或妊娠小鼠和豚鼠的离体子宫无明显影响。给妊娠大鼠灌服醋酸棉酚能使子宫自发收缩明显提高,该作用可被消炎痛拮抗。经醋酸棉酚处理的妊娠大鼠的离体子宫平滑肌对15-Me-PGF₂α的反应比对照组明显提高,醋酸棉酚能降低妊娠大鼠和超排卵大鼠血浆孕酮浓度。结果提示醋酸棉酚兴奋子宫平滑肌作用为雌激素促进;孕激素抑制,促进妊娠大鼠子宫自发收缩可能与其在卵巢水平降低血浆孕酮水平,及促进内源性前列腺素释放有关。更多还原

【Abstract】 The effect of gossypol acetic acid (GAA) on plasma progesterone and uterine activity was observed. It was shown that the plasma levels of progesterone in pregnant and supraovulated rats were reduced after GAA administration, GAA Stimulated the contraction of isolated uteri in mice and guinea pigs receiving oest radiol, but it did not produce the contraction of isolated uteri in pregnant or progesterone-treated mice and guinea pigs. When the pregnant rats were given GAA orally with 5 daily doses of 100 mg/kg, the spontaneous contraction of uterus was enhanced, and the effect of GAA on spontaneous uterine contraction of pregnant rats could be prevented by indomethacin. Based upon the above results it was assumed that the stimulating effect of GAA on uterus could be increased by estrogen and decreased by progestogen. GAA enhanced the spontaneous uterine contraction in pregnant rats might be related to its luteolytie action and endogenous PGs release.更多还原