【摘要】 在家兔慢性实验中,经口给予左旋高诺酮或醋酸左旋高诺酮肟,剂量500μg/天,每周给药6天,连续给药3个月。结果表明,两种孕激素均不影响动物体重的增长;也未引起血清谷-丙转氨酶活性升高;对血清总胆固醇、甘油三酯及高密度脂蛋白-胆固醇水平的轻微影响,与对照组比较,差异无显著意义。给药组之间也未呈现明显差异。病理组织学检查结果,两种孕激素对家兔重要器官无明显毒性损害。器官重量和器官系数与对照组比较,差异均无显著意义。更多还原

【Abstract】 ID sub-chronic study, rabbits were administered Levonorgestrel or Norgestimate, per os, 500μg Per day, 6 clays every week for three months. The results of this comparative study have shown no influence on growth of body weight and no increase of SGPT activity. No statistically significant differences in serum total cholesterol, triglyceride and HDL-C levels were found when compared with control group. Pathological examinition has shown no obvious toxic damage in some important organs. No statistically significant differences in organ weights and organ coefficients between treatment and control groups were observed.更多还原