【摘要】 本文应用随机化双盲法,对三种低剂量含雌、孕甾体激素避孕药(含18-甲基炔诺酮及炔雌醇的复方三相制剂,含18-甲基炔诺酮150μg及炔雌醇30μg的固定剂量制剂,含炔诺酮600μg及炔雌醇35μg的Ⅰ号避孕药)进行比较性研究。共收集合格健康育龄妇女279例;其中复方三相制剂96例,固定剂量制剂93例,Ⅰ号避孕药90例。按生命表法统计,其6个月的每百妇女累积续用率:复方三相制剂82.3,左旋18-甲基炔诺酮/炔雌醇固定剂量制剂81.6,Ⅰ号避孕药80.9,三组间在统计学上无显著差别。副反应的发生率,三组间亦甚相似。有关出血类型:在复方三相制刺中月经周期较为规则,滴血最为少见,行经期长度亦较少受影响。研究证实复方三相制剂是一种有效的低剂量口服避孕药,值得进一步研究。更多还原

【Abstract】 A double-blind randomized clinical study to compare the use effectiveness and bleeding patterns among triphasic preparation (LNG50～125μg/EE30～40μg),microgynon 30 (LNG 150μg/EE 35μg) and pill No. 1 (NET 600μg/EE35μg) had been carried out during Feb.and July, 1983. The recruited volunteers were 96,93 and 90 cases respectively. Using life table calculation, the cumulative continuation rates per 100 women at the end of 24 weeks were 82.3, 81.6 and 80.9. There were no statistical differences between them. The incidences of side effects were also similar. As to the bleeding patterns,the triphasic preparation showed better control in menstrual cycle, less spotting and less effect on the length of menstrual flow. Our results proved that the triphasic preparation which contained much smaller dose of progestogen is an effective low dose oral contraceptive.更多还原