【摘要】 本文报道了用听觉脑干诱发反应(ABR~*)技术探索高胆红素血症(高胆)新生儿的临床检查和ABR反应参量之间的内在联系,为临床预测高胆新生儿听力和神经功能发育提供新的指标.更多还原

【Abstract】 A study of the neurological significance of the parameters of auditory brain-stem responses in newborns (hyperbilirubinemic 34 cases and normal 30 cases) has been done.We can summarize as follows: 1. ABR’s thresholds of the newborns with hyperbilirubinemia distributed mainly in 30-40 dB HL (70%); 2. The absolute latency decreasing degree (ALDD) ( - 0.40±0.50ms) of ABR’s wave Ⅰ in hyperbilirubinemic newborns is less than that (0.328 ±0.355ms) of normal newborns as aging at 0-10 dB RL (P 0.002) (aging 2-7 days’ sub-group versus aging 7-28days’ sub-group), however at 40-50 dB RL ALDDs (0.006 ± 0.586 ms,0.000±0.358ms)between hyperbilirubinemic and normal are approximate (P>0.05); 3. The inte-rpeak latencices ( Ⅰ-Ⅲ 2.85±0.33ms, Ⅲ-Ⅴ 2.43 ± 0.33 ms, Ⅰ-Ⅴ 5.31±0.32 ms ) of ABR in hyperbilirubinemic newborns in aging 2-7 days are longer than that(Ⅰ-Ⅲ 2.42 ± 0.42 ms, Ⅲ-Ⅴ 2.18±0.17 ms, Ⅰ-Ⅴ 4.60±0.31 ms) of ABR in normal newborns at the same aging condition (P 0.006. 0.011, 0.000006, respectively); 4. The comparison of the slopes of latency-intensity function of ABR’s wave Ⅴ between hyperbilirubinemic (32.8±12.9 μsec/dB, 29.4± 10.0 μsec/dB, 28.5±11.4 μsec/dB) and normal (52.4±25.7 μsec/dB, 49.0±29.9 μsec/dB, 45.5 ±20.7 usec/dB) shows a lower quantity of the former (P 0.017,<0.05, 0.029, respectively).On basis of the informations about bio-chemical and symptomatic examination, it is proved that the results of the clinic examinations are in agreement with the parameters of ABR tested.We Would make the conclusion that the ABR’s parameters can be restricted by the value of serum bilirubin, the increasing rate of serum bilirubin, the persistant time of high serum bilirubin concentration and the neurological symptoms in hyperbilirubinemic newborns; otherwise, ALDD of wave Ⅰ at low intensity stimulation (0-10 dB RL), Ⅰ - Ⅲ , Ⅲ - Ⅴ , Ⅰ - Ⅴ IPL, the slope of L-Ⅰ function for wave Ⅴ and ABR threshold can be as an observation indication for audiology, neurology and development of hyperbilirubinemic newborns.更多还原