【摘要】 <正> 由数理统计可知,最大或然估计值有一些优良的性质;在小样本中,参数θ的最大或然估计值θ*的方差最小;在大洋本中最大或然估计值θ*是一致的,近于无偏的,高效,而且渐近地服从正态分布,如果存在充分的估计值时,θ*是最充分的。为了描述一群个体的遗传组成,就需要知道控制各抗原遗传的基因频率,从基因频率可以进一步估计单倍型频率、连锁不平衡参数等遗传参数。基因频率可由遗传型频率及表现型频率估得。但是,有时个体的遗传型不易了解(特别是自细胞分型研究中),常采更多还原

【Abstract】 In the studing of leucocyte antigen, the estimation of leucocyte gene frequ- encies is usually based on the phenotype frequencies of population.On the gro- und of maximum likeIihood method and other principles of mathematical stati- stics, the author obtained a computing method to estimate the gene frequencies, using iteration process, and prepared respectively computing program. Besides used in the studing of leucocyte antigen, the computing method could be used in the other estimations of population genetics in general.更多还原