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用高压液相色谱法测定人尿中胸腺嘧啶乙二醇及胸苷乙二醇
HPLC ASSAY OF THYMINE GLYCOL AND THYMIDINE GLYCOL IN HUMAN URINE
【摘要】 胸腺嘧啶乙二醇是一种DNA氧化产物。我们利用HPLC方法测定了尿中游离的胸腺嘧啶乙二醇和胸苷乙二醇。结果表明:人尿中胸腺嘧啶乙二醇和胸苷乙二醇的含量分别是0.44±0.05,及0.16±0.03nmol/kg体重/天。一个中国人每天排泄这两种乙二醇产物大约36nmol。在男性和女性之间无显著差异。
【Abstract】 We have used HPLC assay to determine free thymine glycol and thymidine glycol in urine. Our results indicate that the amount of thymine glycol and thymidine glycol in human urine are 0.44±0.05, and 0.16 ±0.03nmol/kg of body weight per day respectively. About 36 nmol of the two glycols per day were excreted for Chinese person. No significant difference between female and male.
- 【文献出处】 生物化学杂志 , 编辑部邮箱 ,1987年04期
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