【摘要】 作者建立了快速简便的测定L-18甲基炔诺酮阴道避孕环中的18甲基炔诺酮剩余量的反相高效液相色谱（HPLC）分析法。采用YWG-C₁₈H₃₇柱,甲醇-水流动相,紫外分光光度法（UV）波长254nm检测器,使用炔诺酮作内标化合物。色谱分析前样品环先经切碎并以乙醇-氯仿提取。色谱峰分离完全,方法线性良好,平均回收率为99.98±1.70％（n=15）。本法应用于临床样品测定结果满意。更多还原

【Abstract】 A rapid and simple reversed phase high performance liquid chromatograpbic procedure with a YWG-C18H17 column, eluent consisting of CH3OH and H2O, and UV 254 run detector for determining the residual amount of levonorgestrel inIcvonoj’gestrel contraceptive vaginal rings was established. Sample rings should be fragmented and then extracted with C2H5OH-GHCl3 before chromatographic analysis. Norethindrone was used as an internal standard. Experimental results exhibited absolutely separate chromatographio peaks, good coefficient of correlatior (0.9998) and mean recovery (99.98±1.70, n = 15). This method was used for clinical monitoring with satisfactory results.更多还原