【摘要】 <正> 我室从1975年始将国内当时常用的非纯种大鼠,按兄妹交配、繁殖,现已培育出两系近交系大鼠,命名为TR 1和TR 2,前者已达31代,后者达26代。已在国内一些科研单位使用。本文报告两系大鼠自发性肿瘤发生率,为使用单位提供科学数据。材料及方法一、TR 1系大鼠来自天津药检所,1975年始在本实验室按兄妹(B×S)交配而育成。采用第23～25代共288只,其中(?)105只,(?)183只。二、TR 2系大鼠来自北京中国科学院遗传所。1976年在本室按兄妹交配、繁殖。采用第20～22代共336只,其中(?)186只,(?)150只。三、实验方法:每一品系设未生育组和生育组,更多还原

【Abstract】 The incidence of spontaneously occurring tumors in the selected TR 1 and TR 2inbred strain rats was observed over two years and reported the results of histologicalexaminations as follow. The TR 1 rats used were 288(■ 105;♀183). Mammary gla-nd fibroadenomas in the TR 1 rats were 9.3%(♀) and 1.0%(■), mammary glandadenocarcinomas 1.6% (♀), lung adenomas 1.6% (♀) and 2.9%(■). The TR 2rats used were 336(■186; ♀150). Mammary gland fibroadenomas were 13.3 9%(♀)and 2.2%(■), mammary gland adenocarcinomas 2.7% (♀) and 0.5% (■), lungadenomas 0.7% (♀) and hepatomas 0.3% (1/336)。更多还原