【摘要】 对新型消毒剂碘附Ⅰ号进行了急性毒性(包括经口 LD₅₀、经皮 LD₅₀和粘膜及皮肤的刺激试验)和致敏作用的研究。结果表明:大、小鼠 LD₅₀说明该碘附Ⅰ号属于低毒物质,豚鼠经皮 LD₅₀未能测出。粘膜刺激试验:碘附Ⅰ号原液对眼粘膜有强刺激作用;50%碘附Ⅰ号液有中等刺激作用;25%、5%、2%及1%的碘附Ⅰ号液无任何刺激作用。家兔皮肤刺激试验显示无皮肤刺激作用。豚鼠皮肤致敏试验结果无致敏作用。因此,我们认为碘附Ⅰ号液是一种有前途的皮肤及医疗器械消毒剂。更多还原

【Abstract】 Iodophor-No.1 is a new disinfectant.We carried out the following stu- dies:acute toxicity test and sensitization test of Iodophor-No.1.The re- sults showed that the Iodophor-No.1 belongs to low toxic substance,by the orally taking LD₅₀ test in mice and rats.Acute skin toxicity cannot determine in guinea pigs;irritate test of the mucosa membrance of the eyes by the thick solution of Iodophor-No.1 showed a strong irritate ef- fect 50 per cent Iodophor-No.1 showed middle irritate effect,25,5,2, and 1 per cent are without any irritating properties;skin irritate test of rabbits did not show any irritate effects;The sensitization test by guinea pigs was negative. Therefore,we think that Iodophor-No.1 is a promising disinfectant for skin and medical instrument.更多还原