【摘要】 本文报道了12对芳环取代的-α-卤代桂皮酰胺类化合物的UV及~1H NMR。并通过λmax和~1HNMR谱中酰胺氮上的氢及双键β-烯氢的化学位移判断它们的构型,这种判断结果已为X光衍射确证。更多还原

【Abstract】 UV and 1H NMR of twelve pairs of α-halocinnamamides substituted by aromatic ring are reported. A structure-activity relationship study of a series of(Z) and(E)-N-alkyl-α-halocinnamamides showed that geometrical isomers act differently in the anticonvulsant activty; generally, ( Z ) derivatives are several times more potent than ( E ) isomers in the anticonvulsant activity. Their configurations were assigned by their UV γmax and 1H chemical shifts of protons on the amide group and olefinic bond. The configuration was confirmed by the X-ray diffraction results of one pair of these geometric isomers.更多还原