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α-卤代桂皮酰胺类化合物的UV,~1H NMR及构型研究

THE STUDY ON UV,~1H NMR AND CONFIGURATION OF α-HALOCINNAMAMIDES

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【作者】 王书玉王动乔梁王映芬庞吉海刘维勤李仁利

【Author】 Wang Shuyu Wang Dong Qiao Liang Wang Yingfen Pang Jihai Liu Weichin and Li Renli(Beijing Medical University)

【机构】 北京医科大学药学院波谱室北京医科大学药学院波谱室

【摘要】 本文报道了12对芳环取代的-α-卤代桂皮酰胺类化合物的UV及~1H NMR。并通过λmax和~1HNMR谱中酰胺氮上的氢及双键β-烯氢的化学位移判断它们的构型,这种判断结果已为X光衍射确证。

【Abstract】 UV and 1H NMR of twelve pairs of α-halocinnamamides substituted by aromatic ring are reported. A structure-activity relationship study of a series of(Z) and(E)-N-alkyl-α-halocinnamamides showed that geometrical isomers act differently in the anticonvulsant activty; generally, ( Z ) derivatives are several times more potent than ( E ) isomers in the anticonvulsant activity. Their configurations were assigned by their UV γmax and 1H chemical shifts of protons on the amide group and olefinic bond. The configuration was confirmed by the X-ray diffraction results of one pair of these geometric isomers.

【关键词】 α-卤代桂皮酰胺类化合物UV~1HNMR构型
【Key words】 α-HalocinnamamidesUV1H NMRconfiguration.
【基金】 中国科学院科学基金资助课题;国家医药管理局资助
  • 【文献出处】 波谱学杂志 ,Chinese Journal of Magnetic Resonance , 编辑部邮箱 ,1987年04期
  • 【被引频次】1
  • 【下载频次】24
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