嗜酸性痒疹(Eosinophilic prurigo)的临床表现(附23例临床分析)

【摘要】 在近5年内,我们观察到一组病人(23例),出现痒疹样皮疹,伴有明显地嗜酸细胞增多。其特点是在前胸、后背、腹部、大腿及上肢有密集孤立的瘙痒性丘疹。发疹与饮食、季节无关。腋部、腹股沟淋巴结肿大,无压痛。无肝脾肿大。肝功能正常,γ—球蛋白略增高,IgE 显著增高。所有病例皆嗜酸粒细胞增多,其中嗜酸粒细胞达10—40%者占全部病例的95.5%。骨髓显示嗜酸粒细胞增生。组织病理学改变是不规则棘层肥厚,部份角化不全,海绵形成及表皮下、真皮上层水肿。血管周围有中等度淋巴细胞及嗜酸粒细胞散在于真皮上层及中层。根据临床及组织病理学的特征,本症与其它痒疹不同,因此我们建议命名为“嗜酸性痒疹”。更多还原

【Abstract】 In recent 5 years,we have been abserved that a group of patients (23 cases) with prurigo-like eruptions associated with marked eosino- philia.It’s characterized by single and multiple pruritus papular at chest, back,abdomen,thigh and upper arms.The eruption occurred not related with season or take foods.The papular may be become larger when it was scra- tched.The lymphatic glands was enlargement in axillae and groins which have no tenderness.Liver and spleen are not enlargement.Hepatic functions was normal,v-globuline slight increased,IgE marked increased and eosinophilia was found in all cases (10-40% eosinocyte in WBC,about 95.5% in all cases.).Bone marrow examination presented eosinophilia.The histopathologic changes was irregular acanthosis,partial parakeratosis,spongiosis and edema in lower epidermis and upper dermis.There is perivascular infiltration with moderate lymphocyte and eosinophil cell disseminate in upper and middle dermis.It is different from anather prurigo,according to clinic and histopa- thologic feature so that we recommend that “Eosinophilic Prurigo” should be named.更多还原