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天麻多糖在小鼠体内诱生干扰素的研究

Researching on Interferon Induced in Rats with Polysaccharide of Rhizoma Gastrodiae

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【作者】 朱丽玲; 王建陵; 吴彻; 严红;

【Author】 Zhu Liling

【机构】 南京中医学院微寄教研室; 南京中医学院微寄教研室;

【摘要】 观察了天麻多糖在组织培养上对水泡性口炎病毒(VSV)的直接抑制作用。小鼠口服天麻多糖后,促诱生干扰素的效价为对照组的13倍。腹腔注射后,诱生干扰素的效价为125u/ml—344u/ml,明显地高于对照组(P<0.01).结果提示,天麻多糖除具有传统的抗惊厥及镇静作用外,还具有促进干扰素诱生能力,可望作为一种干扰素诱生剂用于临床。

【Abstract】 It was found that Polysaccharide of Rhizoma Gastrodiae(天麻)was able to inhi- bit the virus,which could infect follicular stomatitis,from normal growing under the cultivation with tissue culture medium;and also it was found that by oral tak- ing this polysaccharide,the rats’valence of interferon induced reached 125?/ml— 344(?)/ml.By comparing the value with that of control group,the difference was significant(P>0.01). This result suggests that polysaccharide of Rhizoma Gastrodiae has the effects not only to suppress the convulsion and calm the mind,which we have alreddy known, but also to induce interferon.Therefore it can be used as an interferon inducer in the clinical practice probably.

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