【摘要】 大白鼠脑室注射海人酸(KA)5天后,检查被动回避行为和脑组织学变化。发现受注射一侧海马的背侧CA3a分区锥体细胞破坏,对长时记忆,特别是长时记忆形成能力有严重损害,对学习和短时记忆无明显影响。增大KA剂量,对锥体细胞的破坏范围也扩大,能波及CA3,CA4和CA1区锥体细胞。双侧注射KA,两侧海马的背侧锥体细胞都有损毁,但对学习记忆行为的损害程度并不增高。这些结果提示,海马背侧CA3a分区锥体细胞在被动回避反应行为的长时记忆形成中有重要意义;长时记忆与学习和短时记忆的形成,在海马结构中可能有不同的神经基础,脑室注射KA后2月,海马锥体细胞的破坏仍未见恢复,长时记忆形成能力的受损亦未能代偿。本文还讨论了海马CA3影响长时记忆过程的可能神经机理。更多还原

【Abstract】 The passive avoidance behavior were examined in 5 days after intraventricular injection of kainic acid (KA) in rats, and the brains were detected histologically. The results showed that the long-term memory, particularly in the process of long-term memory establishment was markedly impaired, but both learning and short-term memory were not influenced on the condition that the pyramidal cells of subdivision CA3a in left dorsal hippocampus were destroyed. The areas of pyramidal cells in hippocampus such as CA3, CA4 and CA1 might be injured with increasing dosages; both sides of pyramidal cells were destroyed by bilateral intraventricular administration, but the impaired degree of learning and memory were not enhanced with increasing dosages. These observation indicate that the pyramidal cells of subdivision CA3a in dorsal hippocampus might play an important role in the process of longterm memory establishment by means of passive avoidance response; it is possible that there exist different neural bases in the hippocampal structure for the long-term memory and the learning and short-term memory. Two months after intraventricular adminitration of KA, the injured pyramidal cells were not recovered, and the deficiency of long-term memory establishment could not be compensated. The possible neural mechanism of hippocampal area CA3 in the process of long-term memory was also discussed in this paper.更多还原