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利福定、氯苯吩嗪和氨苯砜治疗多菌型麻风的近期疗效

Effects of Treatment of Multibacillary Leprosy with RFD, B663 and DDS in a Short Term

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【作者】 陈联芬杨开云

【Author】 Chen Lianfen et al

【机构】 武汉市皮肤病防治所武汉市皮肤病防治所

【摘要】 作者在武汉市皮肤病防治所采用利福定、氯苯吩嗪、氨苯砜联合治疗住院的多菌型麻风45例,经1~2年观察均获明显疗效。初治组和经治组在临床上皮脶均有明显好转,但经治组消退较慢。初冶组治疗一年BI平均减少1.3(37.1%),疗期2年平均减少2.1(52.2%);经治组治疗一年BI平均减少0.9(36.0%),疗期2年平均减少0.8(42.1%)。由于本治疗方案中B663为每月一次监服300mg,皮肤红染轻,易为患者接受,故作者对B663的剂量及用法进行了讨论。

【Abstract】 Good clinical and bacteriological effect was obtained in 45 cases of multibacillary leprosy treated with RFD, B663 and DDS for one to two years. The group, untreated in the past, showed clinical improvement more evident than the treated group, and their BI decreased by 1.3 in the first year and by 2.1 in the second year. The group treated with DDS or DDS plus RFD in the past showed that their BI decreased by 0.9 in the first year and by 0.8 in the second year. With the dose of B663 being only 300mg a month less pigmentation occured.

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