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病毒性乙型肝炎循环HBsAg免疫复合物的比较研究

Comparative Studies of Circulating HBsAg Immune Complexes In Viral Hepatitis

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【作者】 汤家铭葛治华董祥家

【Author】 Tang Jiaming~*, Ge Zhihua~*, Dong Xiangjia~(**) *Department of Microbiology, Shanghai Medical University, **The 3 rd. Affiliated Hospital, China Medical University

【机构】 上海医科大学微生物学教研室中国医科大学三院

【摘要】 <正> 近年来,对乙型肝炎的循环免疫复合物(CIC)研究报道较多,对CIC的抗原抗体成份也作了分析。已有证据表明循环HBsAg免疫复合物(HBsIC)可以沉积在肝外组织引起损伤,但对HBsIC不同抗原抗体比例的研究报道很少。我们用C1q结合试验检测HBsIC,以人工HBsIC为模型,对重症肝炎和急慢性肝炎的HBsIC存在状态作一比较研究。材料和方法一、病例选择按1983年中华医学会全国传染病与寄生虫病专题学术会议通过的诊断

【Abstract】 74 patients with HBV infection have been studied for circulating HBsAg imtnun complexes (HBslC) by using C1q binding test. lt was found that the positive HBsIC in various clinic type of hepatitis B was about 42.9-80%.Using artificial HBsIC as a model to study the HBsIC statuses of different antigen-antibody ratios in patient’s sera, it was found that the HBsIC status in most of subacute, severe, acute and chronic hepatiti-B existed as antigen excess. Antibody excess HBslC was found only in a patient with chronic persistent hepatitis, who was in convalescence.The %of positive HBsIC was higher in patients with elevated GPT than in patients with normal GPT,and HBsIC could also be detected in 52.6% of HBsAg negative patients.Follow-up studies of a patient with acute hepatitis showed that HBslC increased as the titer of HBsAg decreased.

  • 【文献出处】 临床肝胆病杂志 ,Chinese Journal of Clinical Hepatology , 编辑部邮箱 ,1987年01期
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