【摘要】 本实验通过外源性3′,5′环腺苷酸和茶碱对小白鼠肝癌-H₂₂腹水型癌细胞的连续作用,观察到癌细胞的增殖受到明显抑制,伴随有癌细胞膜表面Mg⁺⁺-ATP酶、（Na⁺-K⁺）-ATP酶以及磷酸二酯酶活性明显下降;酶活性变化与膜表面微绒毛的变化,有一定平行关系。更多还原

【Abstract】 The experiment was carried out on Hepatoma-22 ascitic tumor cells of mice in vivo. Daily injection of 2 mg cAMP with 1 mg theophylline into the peritoneal cavity for 7 and 8 days, then these animals were sacrificed. We found that cAMP with theophylline inhibit the growth of tumor cells of Hepatoma-22 ascitic and decrease the activity of Mg⁺⁺, （Na⁺-K⁺）-ATPase and cAMP-PDE on the cell surface of H-22 tumor cells of mice by cytochemical electron microscopy. Exogenic cAMP and theophlline decrease the activities of these enzymes and elevate the intracellular content of cAMP. These may indicate the reversion transformation of the cancer cell.更多还原