【摘要】 用经中药穿心莲苦味素内酯进行中期妊娠引产的胎盘标本12例,并以正常中期妊娠钳夹引产的胎盘6例作为对照标本,进行组织学和组织化学的观察;还用免抗HCG血清PAP法,进行免疫组织化学的观察。穿心莲引产的胎盘绒毛合体滋养层胞质嗜碱性普遍减弱,RNA染色反应减弱,HCG免疫反应也普遍下降。5例用药后自然娩出胎盘的蜕膜细胞AcP酶反应升高;而2例用药后人工引产胎盘的蜕膜细胞AcP酶反应未升高。这些改变表明,中药穿心莲使大部分的胎盘合体滋养层受到损伤,并使其合成HCG的功能下降。5例引产成功者,蜕膜细胞AcP酶反应升高,2例引产不成功者,蜕膜细胞AcP酶反应未升高,提示溶酶体酶的改变,可能与引产中子宫收缩的发动有一定关系。更多还原

【Abstract】 12 cases of human placentas were obtained after administration of Chinese medicinal herb (Chuan-Xin-Lian) -induced abortion during mid-pregnancy. Six placentas from curettage induced abortion during mid-pregnancy were used as controls. All the specimens were studied histochemically and immunohistochemically by using antiserum to HCG with PAP method. In most of the specimens from women treated during mid-pregnancy, we observed a decreased immunoreaction of antiserum to HCG and a decrease of RNA content in the syncytiotrophoblasts. Increased activity of acid phosphatase in dccidual cells was observed during mid-pregnancy. These findings indicate that during mid-pregnancy, Chinese medicinal herb (Chuan-Xin-Lian) can reduce the synthesis of HCG in syncytiotrophoblasts and can initiate uterine contractions, so that abortion results. The possibility that the changes of lysosomal enzymes are involved in the initiation of uterine contractions is disscused.更多还原