【摘要】 本文介绍了¹²⁵Ⅰ—4—碘苯氧乙酸（增产灵）的合成方法,采用氯胺T氧化法新合成工艺。以苯酚和一氯乙酸为原料,先制成中间产物苯氧乙酸,然后在氯胺T存在下,使其与¹²⁵Ⅰ-碘化钠反应得到¹²⁵Ⅰ—4—碘苯氧乙酸。产品经硅胶薄层分析,R_f=0.84,比放射性为1.83mci/mMol,放化纯度>90％,产率为70％,适用于示踪研究。更多还原

【Abstract】 The method of preparation of 125I-4-iodo-phenoxyacetic acid is described. The intermediate phenoxyacetic acid were synthesized from phenol and chloroacetic acid. Then the proposed compound was obtained when phenoxyacetic acid reacted with I-sodium iodide in the presence of chloramine-T. The product by using silica gel thin layer chromatography analysis showed that Rf= 0.84, the radiochemical purity and specific activity was 90% and 1.83mci/mMol, the radiochemical yield was 70%. The product was suitable for tracer study. (CH)更多还原