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二氯异氰尿酸钠的致突变作用评价

EVALUATION OF THE MUTAGENICITY OF SODIUM DICHLOROISOCYANURATE BY AMES, MICRONUCLEI AND UDS TESTS

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【作者】 蒋天蓉曾昭贤曾祥贵李良宏王浴生

【Author】 Jiang Tian-Rong Zheng Zao-Xian Zheng Xiang-Gui Li Liang-Hong Wang Yu-Sheng (Dept. of Pharmacology, West China Univ. of Medical Sciences Chengdu.)

【机构】 华西医科大学药理学教研室华西医科大学环境卫生教研室华西医科大学药理学教研室 成都成都成都

【摘要】 本文用沙门氏菌回复试验(Ames试验)、小鼠骨髓多染红细胞微核试验及人外用血淋巴细胞程序外DNA合成试验(UDS)评价新型消毒剂二氯异氰尿酸钠的致突变作用。这三种试验均显示该化合物无致突变作用。

【Abstract】 The mutagenicity of a new disinfectant, the china-made Sodium Dichloroisocyanurate (DccNa), was determined by Ames, Micronuclei and the UDS Tests. The Ames Tests was performed with strain TA979 TA989 TA100 and TA102, with and without metabolic activation system (+S9 mix.). The Micronuclei Test was observed in red cells of mice bone marrow, and the UDS was measured by the[3H]-TdR incorporation into human peripheral blood lymphocyte. All of the three tests show that the DccNa was absent of mutagenicity.

  • 【文献出处】 华西药学杂志 ,West China Journal of Pharmaceutical Sciences , 编辑部邮箱 ,1987年03期
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