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高粘滞综合征时的微循环改变

Changes of microcirculation in hyperviscosity syndrome

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【作者】 王柏生魏经汉汪丽娟党瑜华邓春玲邢仲莲吴兴祥杨文浩黄幼田刘守彦马秀云李海燕

【Author】 Wang Baisheng Department of Pathophysiology, Henan Medical University

【机构】 河南医科大学病理生理学教研室河南医科大学第一附属医院内科新郑卷烟厂职工医院河南医科大学病理生理学教研室

【摘要】 本文对冠心病、高血压病、动脉硬化症、肺心病、糖尿病及甲状腺机能低下等共967例患者作血液流变学检查的同时,观察其甲皱微循环,并以年龄可比的健康人125例为对照。结果表明:与健康人相比,上述各疾病组患者的全血粘度、血浆粘度明显增高(P<0.001),血液均处于高粘滞状态;甲皱微循环的血流速度显著减慢(P<0.01~0.001)、血管袢排列紊乱、异常血管袢增多且异常程度严重(P<0.01~0.001)。本结果提示:(1)上述各种疾病患者的血液均处于高粘滞状态;(2)高粘滞综合征时微循环出现明显障碍。此外,本结果也为血液流变学疗法的研究提供了依据。

【Abstract】 The observation of microcirculation of nailfold was made in 967 patients with different kindsof diseases, e.g. coronary heart disease, hypertension, atherosclerosis, pulmonary-heart disease,diabetes and hypothyroidism. 125 healthy persons with comparable ages were taken as controls.The results show that, compared with the controls, the patients with any kind of diseases mention-ed above had higher whole blood viscosity and plasma viscosity (p<0.001), which means that the bloodwas of hyperviscosity; that the speed of blood flow in microcirculation of nailfold decreased significan-tly; that the capillary loops were arranged in disorder; and that abnormal capillary loops increa-sed and the abnormality was severe (p<0.01~0.001). The results indicate: (1) patients with anykind of diseases mentioned above had blood hyperviscosity; (2) there were obvious impedimentin microcirculation in blood hyperviscosity syndrome. Furthermore, this work provides the basisfor the study of hemorheological treatment.

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