【摘要】 在不同实验动物模型上,丙戊酸钠抗氯化钡性大鼠心律失常作用明显强于奎尼丁和利多卡因等,与心得安相当;抗肾上腺素性豚鼠心律失常作用,与异搏定相当,提高家兔电室颤阈值的作用大于心得安,但比利多卡因弱;对大鼠坐骨神经的局部麻醉作用弱于奎尼丁。本品的抗心律失常作用与自主神经活动无关;对心率影响小;对乙酰胆碱性狗心房颤动无效,更多还原

【Abstract】 The LD₅₀of sodium valproate（VPA）,propranolol（PRO）,verapamil（VRP）,lidocaine（LDC）,quinidine（QND）and sodium phenytoin given to mice intrave-nosly was determined.The antiarrhythmic action of these drugs on several modelswas compared at the equitoxic doses(the same fractions of LD₅₀).The action ofVPA against the arrhythmia induced by iv BaCl₂ was similar to that of PRO butstronger than that of QND and LDC in anesthetized rats.The effects of VPA onarrhythmia induced by iv adrenalin were similar to that of VRP in anesthetizedguinea pigs.The activity of VPA to raise electrical ventricular fibrillationthresholds was stronger than that of PRO and less effective than that of LDC inanesthetized rabbits.VPA was ineffective in prevention of atrium fibrillationinduced by topical application of acetylcholine on right atrium in anesthetizeddogs,and it produced less local anesthesia on the sciatic nerves than that of QNDin rats.Antiarrhythmic effect of VPA was not influenced by activity of theautonomic nerve system.更多还原