【摘要】 <正> 豆腐果甙(Helicid,简称Hel)系中国科学院昆明植物研究所从山龙眼科萝卜树(Heliciaerratica Hook)的果实中提取的一种成分。其化学名为4’-甲酰基苯基-β-D-吡喃阿洛糖甙(4’-formyl-pheny-β-allopyranoside)。Hel有镇静、催眠和一定的抗惊厥作用,亦可使氨基硫脲(TSC)降低的小鼠脑中γ-氨基丁酸(GABA)水平恢复正常。为此,我们用放射性酶测更多还原

【Abstract】 Effects of Helicid (Hel) on glutamate decarbcxylase (GAD) and γ-aminobutyric acid transaminase (GABA-T) in the brain of normal and convulsive mice elicited by thiose-micarbazide (TSC) were studied by isotope paper chromatography. It showed that there was no obvious effect of Hel on GAD of normal or on GABA-T of normal and convulsive mice, but Hel could recover the GAD activity inhibited by TSC, which may be relative to its strengthening of inhibition of central nervous system更多还原