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高碘与低碘实验动物甲状腺肿模型的对比研究

THE COMPARISON BETWEEN IODINE-DEFICIENT AND IODINE-EXCESS GOITER IN MICE

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【作者】 朱惠民高优真姚玉霞许立琴王凤荣王俊灵严霞尹桂山杜秀全张牧霞于志恒

【Author】 Zhu Huimin Gao Youzhen Yao Yuxia Xu Liqin Department of Hygiene Wang Fengrung Wang Junling Yan Xia Yin Guishan Du Xiuquan Zhang Muxia Department of Experimental Pathology Department of Biochemistry Guide Yu Zhiheng

【机构】 河北医学院卫生学教研室河北医学院卫生学教研室河北医学院实验病理教研室河北医学院生物化学研究室

【摘要】 在同一实验室用高碘和低碘饲料对同一种动物成功地诱发了高碘和低碘甲状腺肿。甲状腺肿发生率:低碘组84.21%,高碘组88.88%,对照组0%。实验证明:高碘和低碘甲状腺肿在形态和功能等方面均存在着明显的差异。作者认为,高碘甲状腺肿的发病机理与低碘甲状腺肿可能是不同的。

【Abstract】 Two kinds of goiters were formed in mice by feeding with iodine-deficient and iodine-excess foods in our laboratory. The incidence of goiter in iodine-deficient group was 84.21%, in iodine-excess group was 88.88%, and in the control was 0.00%. This work proved that there was significant difference between iodine-deficient and iodine-excess goiters, either in the morphology or in the function of thyroid. According to these data authors considered that the mechanism of iodine-excess goiter probably different to iodine-deficient goiter.

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