【摘要】 以不同剂量的苯芘碘油溶液分3组(Ⅰ组,5mg×2;Ⅱ组10mg×2;Ⅲ组,15mg×2),两次(间隔4周)肺叶支气管灌注诱发Wistar大鼠肺癌的研究结果指出:40～75周内,Ⅲ组诱癌率高达55％(11/20,鳞癌10,腺癌1),而其它两组诱癌率分别为3.2％(1/31)及6.6％(1/15)与对照组(0/28)相比,差异无显著性。本法诱癌率高。又不需表面活性剂或载尘,可做为研究呼吸道肿瘤的病因学、发病学和预防医学的标准材料。更多还原

【Abstract】 Three groups of rats received twice at four-week interval three different doses of benzo(a)pyrene iodized oil sulution(5mg×2 for group I,10mg× 2 for group Ⅱand 15mg×2 for group Ⅲ)by means of intralobar bronchial instillation to induce lung cancer.Within 40～75 weeks,the lung cancer incidence in group Ⅲ was 55%(11/20,10 cases of squamous cell carcinoma, and 1 case of adencarcinoma),and those of the other two groups were 3.2% (1/31)and 6.6%(1/15)respectively,making no obvious difforence with that of the control group(0/28).These findings might be used as standard data for studying etiology,pathogenesis and preventive medicine of respec- tory tract cancer.更多还原