【摘要】 1987年2～3月,湖北省29个县、市的中学发生红斑性肢痛症流行。我们调查5所中学的发病率平均为12％,其中男、女发病率分别为6.4％和28.6％,住读生和走读生的发病率分别为13.5％和2.2％。临床表现有双肢脚趾、脚掌针刺样痛,伴有脚发红、充血、水肿,少数人伴有发烧、心慌、头痛等。外周血小板减少、红细胞体积增大。调查中还发现,60.6％的患者病前曾患感冒,91.2％有咽充血或咽炎。因此,作者认为本病的发生可能与病毒呼吸道感染、血小板在肢端小动脉内的激活和聚集有关。更多还原

【Abstract】 There happened an epidemic of erythromelalgia among the secondary school students in Hubei in February and March, 1987. A survey in 5 secondary schools revealed that the average incidence of the disease was 12％, with an incidence of 13.5％ and 2.2％ respectively for the boarders and the nonresident students. The disease was clinically characterized by burning pain in the toes and soles of both feet and redness, congestion, and edema of the foot, with a small number of the patients having fever, palpitation and headache. The laboratory finding included thrombocytopenia and increase of the mean red blood cell volume. The survey also demonstated that 60.6％ of the patients had cold before the onset of erythromelalgia and 91.2％ had pharynx or pharyngitis when examined. Therefore, we suggest that the pathogenesis of erythromelalgia may be connected with viral infection of the respiratory tract, resulting in type Ⅲ allergy and subsequently aggregation and activation of the thrombocytes in the arterioles of the extremities.更多还原