【摘要】 本文报道了苯妥英钠慢性中毒的癫痫患儿21例,经血药浓度测定及时明确诊断。总结和讨论了苯妥英钠中毒的儿科临床特点。重点指出苯妥英钠慢性中毒的中枢神经系统症状,除了临床熟知的眼球震颤、共济失调和昏睡外,还有惊厥恶化、反应迟钝及言语障碍等症。而后者更为突出和常见,但既往易被忽视。中毒患儿若在血药浓度监测下调整剂量,均可于3天至3周内完全恢复。本文还对预防苯妥英钠中毒做了必要的讨论。更多还原

【Abstract】 The phenytoin-induced toxicity in 21 epileptic children is reported. All of patients recovered by reducing or discontinuing theadministration of phenytoin confirmed by monitoring phenytoin bloodlevels. Clinical features of chronic toxicity of phenytoin in children arediscussed. The neurological manifestation is emphasized such as increasein seizure frequency (86%), dull response (71%), ataxia (67%), nys-tagmus (56%) and speech difficulties (52%). Besides the well-knownnystagmus and ataxia, another symptoms are also the common featuresin phenytoin toxicity which were overlooked before. All the patients completely recovered within 3 days to 3 weeks afterthe beginning of treatment. It will also be discussed the monitoring ofblood levels of phenytoin and the prevention of phenytoin toxicity inthis paper.更多还原