【摘要】 本文通过启东县肝癌病例组与健康对照组、在平衡饮水致癌因素条件下,经7个HBV感染标志检验结果,认为除饮水因素外,HBV感染在肝癌形成中也起一定作用。更多还原

【Abstract】 A case-control study was carried out to determine the relationship between HBV infection and hepatocellular cancer. Sixty-nine cases of hepatocellular cancer were provided by Institute of Hepatic Cancer Research in Qidong County and 138 persons were selected to match for sex, age and residence at a ratio of 1:2 as the controls. Seven HBV markers were examined for each person. The overall infection rates of cases and controls were 97.10% and 69.57% respectively and the difference was statistically significant. The average numbers of positive markerper person in these two groups were 2.42 and 1.30 respectively. The positivity rates of HBsAg, antiHBc IgM, HBV -DNA in the cases were higher than those in the controls. On the contrary, the positivity rate of anti-HBs in the controls was significantly higher than that in the cases. The rates of markers indicating virus replication (HBeAg, anti-HBc IgM, HBV-DNA) in the cases and controls were 40.58% and 17.39% respectively and the difference was statistically significant. The rate of simultaneous appearance of several such markers in the patients was higher than that in controls. The odds ratio of hepatocellular cancer in the cases increased with increasing number of positive markers.In addition to the factor of drinking water, hepatitis B is also closely associated with hepatocellular cancer in Qidong County.更多还原