【摘要】 乙双吗啉(AT₁₇₂₇)是我国自行合成的派嗪二酮类抗肿瘤药物,它的放射增敏性近年来引起了各方面的关注。本文以人肺腺癌细胞系SPC—A—1为材料,用体外细胞集落形成法研究了乙双吗啉在乏氧条件下的辐射增敏性,结果表明当药物浓度为0.15m mol/L时,增敏比为1.33。对现有资料进行分析,提出乙双吗啉可能以某种方式作用于乏氧的肿瘤细胞。更多还原

【Abstract】 Bimolane (AT₁₇₂₇), a new antitumour drug, was synthesized inChina. Of late years, attention has been paid to the radiosensitizing activity of AT₁₇₂₇.In present study, this effect has been studied with hypoxic human lung adeno-carcino-ma SPC-A-1 using colony formation assay in vitro. The restlt obtained showed thatthe SER（Sensitivity Enhancement Ratio） was 1.33 when the concentration of AT₁₇₂₇was 0.15 m mol/L. Basing on the analysis of some results including those of solid tumour of mice, itis reasonable that AT₁₇₂₇ has radiosensitizing effect on hypoxic tumour cells.更多还原