【摘要】 本文报道依米丁中毒性心肌损害实验模型的复制方法,并观察亚硒酸钢对此种损害的保护作用。实验结果表明,依米丁组大鼠(盐酸依米丁15mg/kg一次腹腔注射)出现中毒性心肌损害症状,并有心电图改变,血清磷酸肌酸激酶(SCPK)明显增高以及心肌组织病理学改变等。硒+依米丁组大鼠(每日腹腔注射亚硒酸钠200μg/kg,连续五天,第六天再给依米丁)上述指标均比依米丁组动物减轻或降低,说明亚硒酸钠对依米丁诱发的心肌损害有一定的保护作用。更多还原

【Abstract】 This paper reports the effecf of sodium selenite on the emetine induced myocardial damage in rats.Results indicate that emetine hydrochloride at a single 15mg/kg dose ip may induce myocardial damage in rats.The animals presented toxic symptoms,changes on EKG,increase of serum CPK,and degenerative changes of myocardium.If the animals were given sodium selenite(200μg/kg/day,ip)for five consecutive days previous to emetine given,then the above changes were diminished or decreased.These results show that the sodium selenite may have some protective effects on the emetine induced myocardial da- mage in rats.更多还原