【摘要】 本文回顾性研究35例重型乙型肝炎中δ因子感染状态。选择近期病后>20天的血清标本(每例一份)用EIA法(美Abbott试剂盒)进行抗-δ测定。结果:抗δ(+)共12/35例(34.3％),其中亚重肝3/13例(23.1％),慢重肝9/22例(40.9％),每例都有3～5项标记HBV感染血清学指标。平均年龄34岁(19～51岁),皆为男性汉族,1例贵州籍,余均为川籍。抗δ(+)的12例重肝患者中,3例亚重肝病情有再度加重历史;9例既往急性肝炎史,其中5例证实长期携带HBsAg。近期发病多进展迅速,推测δ感染对病情恶化可能有一定影响。更多还原

【Abstract】 The paper is to report a retrospective study on delta antigen infection in 35 patients with severe hepatitis B (13 subacute and 22 chronic cases).One serum sample from each patients was collected at least 21 days (21～156 days)after the last attack of the disease,and anti-delta antigen was tested with EIA method (Abbot kit made in USA).The upper limit of O.D.value for positive resultswas calculated as 0.391.It was found that anti-delta antigen was positive in 12 cases(34.3%)out of the 35. 23.1%(3/13)of the subacute and 40.9%(9/22) of the chronic cases were positive.There were 3～5 serological parameters indicating HBV infection in each case.All the 12 positive patients were males of Han Nationality with a mean age of 34 years (a range of 19 to 51).11 were from Sichuan province and only 1 from Guizhou.3 were subacute cases without previous history of hepatitis,and aggravation of the clinical condition occurred in their course;there was a history of acute icteric hepatitis in the remaining 9 cases and 5 out of the 9 were long-term HBsAg carriers.The recent attack of the disease often showed a rapid progression to the severe stage within a month.It is suggested that delta antigen might be one of the factors leading to the aggravation of viral hepatitis.更多还原