【摘要】 这是一次完全剔除爆震因素的急性声创伤实验研究。各组实验豚鼠均以中心频率1000Hz的(?)频带噪声,声压级为130dB,暴露1h,然后分组分期处死制片和镜检观察。在噪声暴露前和处死制片前各动物均分别作皮层诱发电位测定阈值,以估计听力。结果表明早期(当日)听力损失较重而结构改变较微,晚期(2周后)听力损伤较轻而结构改变较重。内耳声创伤的机理可能有局部机械损伤和代谢改变两方面,早期的表现以机械损伤为主,无爆震因素的急性声创伤,机械损伤轻微,而晚期较明显的结构改变,则可能是局部代谢改变的后果。更多还原

【Abstract】 This is an experimental research into acute acoustic trauma free entirely from any explosive factor.The guinea pigs used in the different research groups of this experiment were exposed to narrow band noise of central frequency 1000 Hz and SPL 130 dB for one hour.Then the animals were killed and the cochlear basilar membranes were prepared into specimens at different periods for microscopic examination. Before the animals were exposed to noise, and were killed for preparation of specimens, the threshold values of the evoked potential of the cerebral cortex were respectively determined in the different groups so as to evaluate the hearing.The results show that the hearing loss was more serious and structural modification was slight at the earlier stage(i.e.on the day)and vice versa at the later stage (two weeks after).The mechanism of acoustic trauma may involve two aspects, i.e.local mechanical trauma and metabolic changes.At the earlier stage the main indication is mechanical trauma while at the later stage the structural modification is more evident, which may be induced by local metabolic changes.更多还原