【摘要】 与AS有关的各疾病患者组的RCT显著地低于健康人组。将冠心病组与健康人组的TC±10mg/dL,HDL-ch±2mg/dL,VLDL-ch±2mg/dL配对比较RCT,仍然是患者组RCT显著下降。ApoE遗传表型的分布,发现健康人群无E2/2型,而E2/2型与Ⅲ型高血脂密切相关,E2/2型患者的RCT显著地低于其他各ApoE遗传表型。本研究提出的动物房室模型指出,从一个房室到另一个房室的ch代谢和RCT的动力学曲线可以用系统辨识的方法测定,健康兔与糖尿病兔的RCT有一定差别。更多还原

【Abstract】 Rate of cholesterol transfer (RCT) has been detected in patients with coronary heart diseases, hy-perlipidemia, diabetes, uremia, cerebrovascular disease, hypertension, hepatosis to be markedly lowerthan that in controls. Patients matched with controls for TC within±10 mg/dl, HDL-ch within±2mg/dl, VLDL-ch within±2mg/dl also had lower RCT. Apo E phenotypes were determined in patients aswell as in controls. None with E 2/2 was detected in controls. RCT in patients with E 2/2 wasdetected to be markedly lower than that in the rest of Apo E phenotypes. The report provides acompartmental model which describes plasma ch metabolism in lipoproteins, liver and other tissues ofrabbits. According to the data obtained through measurement, the compartmental system is identifi-able. The rate constants from one comparment to another and the ch metabolism dynamic curve canbe estimated by means of the system identification. The rate constants were different between controland diabetic rabbits.更多还原