【摘要】 以尿中N-亚硝基脯氨酸(NPRO)量为指标,研究刺梨汁阻断人体内N-亚硝基化合物(NNC)合成。10名志愿者摄入300mg硝酸钠和500mg L-脯氨酸后,尿NPRO量平均为63,29nmol,显著高于本底水平(20.21nmol)。同时摄入10ml刺梨汁(含75mg维生素C),其含量降至16.08nmol。此值低于同时摄入75mg维生素C之量(27.59nmol)。证明刺梨汁能阻断人体内NNC合成。更多还原

【Abstract】 Inhibitory effect of Ci Li (Rosa roxburghii) juice on endogenous formation of N-nitrosocompound (NNC) in humans was studied by measuring urinary excretion of N-nitrosoproline(NPRO). The mean 24h NPRO excretion of 10 volunteers after ingesting 300 mg sodium nitrateand 500 mg L-proline was 63.29 nmol, significantly higher than that of dosing no precursors (20.21nmol). NPRO excretion of volunteers reduced to 16.08 nmol in consequence of taking 10 ml Ci Lijuice (contain 75 mg vitamin C) together with the precursors, and this amount was significantlylower than that of ingesting the precursors with 75 mg vitamin C (27.59 nmol). The results are indentical with that found in experiment on rats, and confirm that Ci Li juice,as a natural food, can reduce or eliminate human exposure to endogenous NNC and that in additionto vitamin C, certain component(s) of Ci Li juice can also inhibit NNC formation in vivo.更多还原