【摘要】 应用免疫过氧化酶技术鉴定甲状腺球蛋白,对甲状腺滤泡源性癌,犹如一种免疫组织化学的标记。本文研究了49例原发性甲状腺癌,24例良性甲状腺病变,2例非滤泡性癌,6例甲状腺癌的淋巴结转移,5例非甲状腺癌的淋巴结转移及13例甲状腺外的癌。所有滤泡源性肿瘤及慢性甲状腺炎显示甲状腺球蛋白阳性,而所有非滤泡源性肿瘤,淋巴结的非甲状腺癌转移及甲状腺外癌均为阴性。6例未分化癌中有5例阳性。说明甲状腺球蛋白的免疫组织化学显示法是证明甲状腺滤泡细胞源性癌的一种敏感而又特异的方法。对区别淋巴结的甲状腺滤泡源性与非甲状腺源性癌是一种最好的方法。更多还原

【Abstract】 Employing immunoperoxidase technique to determine the value of thyroglobulin as an immuno-histochemical marker for thyroid follicular cell origin carcinomas, we studied 49 cases of primarythyroid carcinomas, 24 of benign thyroid lesions, 2 of thyroid nonfollicular cell origin carcinomas, 6 ofmetastatic thyroid carcinomas in lymph nodes, 5 of nonthyroid carcinomas in lymph nodes, 13 ofextrathyroidal carcinomas. All folicular orign neoplasms and chronic thyroiditis regardless of theirmorphologic variation, revealed positively for thyroglobulin reactions, whereas all nonfollicularorigin neoplasms, nonthyroid carcinomas in lymph nodes and extrathyroid carcinomas demonstratednegative staining reactions. 5 of 6 cases of undifferentiated thyroid carcinomas showed positivestaining reactions. It is evidenced that immunohistochemical demonstration of thyroglobulin is asensitive and specific method of identifying thyroid follicular cell origin carcinomas. It is the bestmeans of distinguishing metastatic deposits of thyroid follicular origin from those of nonthyroidorigin.更多还原